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This medicine SHOULD NOT BE USED in the following cases: allergy to this medicine, including angioneurotic oedema-type reactions; during the second and third trimesters of pregnancy; in general, this medicine should not be used during the first trimester of pregnancy or during lactation, unless the doctor advises otherwise; Diabetes or impaired kidney function and is treated with a blood pressure lowering medicine containing aliskiren; Concomitant use with sacubitril/valsartan (see "Precautions" and "Interactions"); Extracorporeal treatments leading to contact of blood with negatively charged surfaces (see "Interactions"); Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see "Precautions").
The drug is generally not recommended in combination with potassium-sparing diuretics, potassium salts, lithium and estramustine (see "Interactions").
